Publications by authors named "L F Nikolajsen"

Article Synopsis
  • Postoperative pain management is challenging for patients undergoing robot-assisted cystectomy, and researchers studied whether a single dose of intraoperative methadone could help reduce pain and the need for opioids post-surgery.
  • In a clinical trial with 114 patients, those receiving methadone had similar opioid requirements compared to those getting morphine at both 3 and 24 hours after surgery, but pain levels were lower in the morphine group at 48 hours.
  • Patient satisfaction was higher for those given methadone at 24 hours, indicating that while methadone didn't reduce opioid use or pain intensity, it may contribute to greater overall satisfaction.
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Objectives: To estimate the prevalence and severity of patient-reported physical and non-physical harm following surgery cancellation.

Design: Cross-sectional study.

Setting: A large Danish university hospital.

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Background: Children undergoing outpatient surgery are at risk of inadequate postoperative pain control. Methadone has a long duration of action and an intraoperative dose may provide stable analgesia throughout the postoperative period. Intraoperative methadone has been shown to improve pain control in adolescents but its use for postoperative pain in pediatric patients undergoing outpatient surgery has not been studied before.

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Chronic postsurgical pain (CPSP) is a highly prevalent condition. To improve CPSP management, we aimed to develop and internally validate generalizable point-of-care risk tools for preoperative and postoperative prediction of CPSP 3 months after surgery. A multicentre, prospective, cohort study in adult patients undergoing elective surgery was conducted between May 2021 and May 2023.

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Background: Acute post-surgical pain is managed inadequately in many patients undergoing surgery. Several prognostic risk prediction models have been developed to identify patients at high risk of developing moderate to severe acute post-surgical pain. The aim of this systematic review was to describe and evaluate the methodological conduct of these prediction models.

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