Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients.

Background: Salbutamol, a short-acting β-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes. Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient.

Phytoceutical isoquercitrin and ethanolic extracts from pequi (Caryocar coriaceum Wittm) reverse alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio).

Pharmacotherapy in Alcohol Withdrawal Syndrome (AWS), which is a mental disorder, generally involves benzodiazepines due to their action via GABA, but their side effects, such as excessive sedation, mental confusion and risk of dependence, are considerable. It is important to investigate the anxiolytic potential of plants such as Caryocar coriaceum, due to the presence of secondary metabolic compounds, such as isoquercitrin, capable of promoting the reduction of anxiety during AWS. We evaluated the anxiolytic-like potential of ethanolic extracts from the leaves (EEPL) and pulp (EEPP) of C.

Psychological distress and the COVID-19 pandemic: the role of personality and coping strategies.

Personality traits and coping strategies significantly predict predisposition to psychopathology. This study aimed to examine the predictive role of coping strategies in psychological distress during the COVID-19 pandemic in a sample of Portuguese individuals, considering personality and sociodemographic variables. Data were collected using Google Forms from 2402 individuals (86.