Cough recognition in pneumoconiosis patients based on a flexible patch with an embedded ACC sensor for remote monitoring.

Background: Many respiratory diseases such as pneumoconiosis require to close monitor the symptoms such as abnormal respiration and cough. This study introduces an automated, nonintrusive method for detecting cough events in clinical settings using a flexible chest patch with tri-axial acceleration sensors.

Methods: Twenty-five young healthy persons (hereinafter referred to as healthy adults) and twenty-five clinically diagnosed pneumoconiosis patients (hereinafter referred to as patients) participated in the experiment by wearing a flexible chest patch with an embedded ACC sensor.

Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues.

The phenotypic and functional states of cells are modulated by a complex interactive molecular hierarchy of multiple omics layers, involving the genome, epigenome, transcriptome, proteome and metabolome. Spatial omics approaches have enabled the study of these layers in tissue context but are often limited to one or two modalities, offering an incomplete view of cellular identity. Here we present spatial-Mux-seq, a multimodal spatial technology that allows simultaneous profiling of five different modalities: two histone modifications, chromatin accessibility, whole transcriptome and a panel of proteins at tissue scale and cellular level in a spatially resolved manner.

Molecular Mechanism of Unexpected Metal-Independent Hydroxyl Radical Production by Mercaptotriazole and HO.

It is well known that hydroxyl radical (OH) can be largely produced either through the classic iron-mediated inorganic-Fenton system or our recently discovered haloquinones/HO organic-Fenton-like system, but rarely produced via thiol compounds. Here, unexpectedly, we found that OH can be unequivocally generated by incubation of HO and mercaptotriazole (MTZ), a typical heterocyclic thiol which has been used as an environmentally friendly corrosion inhibitor for mild steel. By the complementary applications of HPLC-MS and oxygen-18 isotope-labeling method, MTZ-derived sulfenic (MTZ-SOH) and sulfinic acids were detected and identified as transient intermediates, and sulfonic acid as final products.

Awakening n-π* electron transition in structurally distorted g-CN nanosheets via hexamethylenetetramine-involved supercritical CO treatment towards efficient photocatalytic H production.

Graphitic carbon nitride (g-CN) has been regarded as highly potential photocatalyst for solar energy utilization. However, the restricted absorption of visible light for pristine g-CN significantly limits the solar-light-driven chemical reaction efficiency. Herein, structurally distorted g-CN nanosheets with awakened n-π* electron transition were successfully synthesized through hexamethylenetetramine (HMTA)-involved supercritical CO (scCO) treatment and following pyrolysis of melamine precursor.

Immobilization of Peniophora incarnata F1 in PVA-SA-biochar matrix and its degradation performance and mechanism for erythromycin degradation.

Erythromycin is becoming one of the most common contaminants detected in surface water and wastewater, which poses a potential risk to ecological systems and human health. Until now, there is still no effective way to eliminate it. Herein, a novel and efficient erythromycin-degrading fungus Peniophora incarnata F1, capable of utilizing erythromycin as its sole source of carbon and energy, was isolated from contaminated sludge.