Gut-kidney interaction reinforces dapagliflozin-mediated alleviation in diabetic nephropathy.

Intestinal microbiota are pathophysiologically involved in diabetic nephropathy (DN). Dapagliflozin, recognized for its blood glucose-lowering effect, has demonstrated efficacy in improving DN. However, the mechanisms beyond glycemic control that mediate the impact of dapagliflozin on DN remain unclear.

Exploring Resources and Reasoning Practices in Socioscientific System Modeling for Justice-Centered Science Education.

Integrating science education with social justice is vital for preparing students to critically address significant societal issues like climate change and pandemics. This study examines the effectiveness of socioscientific system modeling as a tool within Justice-Centered Science Pedagogy (JCSP) to enhance middle school students' understanding of social justice science issues. It focuses on how system modeling can scaffold students' reasoning about complex social systems, informed by their lived experiences, cultural backgrounds, and social identities.

Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications.

Cryptotanshinone (CTS) is an important active ingredient of Bge. In recent years, its remarkable pharmacological effects have triggered extensive and in-depth studies. The aim of this study is to retrieve the latest research progress on CTS and provide prospects for future research.

A High-Precision Real-Time Temperature Acquisition Method Based on Magnetic Nanoparticles.

The unique magnetothermal properties of magnetic nanoparticles enable the development of a high-precision, real-time, noninvasive temperature measurement method with significant potential in the biomedical field. Based on a low-frequency alternating magnetic field excitation model, we construct two additional magnetic field excitation models-alternating current-direct current superposition and dual-frequency superposition-to extract harmonic amplitude components from the magnetization response. To increase the accuracy of harmonic information acquisition, the effects of the truncation error, excitation magnetic field frequency, and amplitude are thoroughly analyzed, and optimal parameter values are selected to minimize the error.