[Clinical and anamnestic analysis of multiple primary neoplasms with lesions of the endometrium in women of the Novosibirsk region].

Based on the study of 60 women who were treated at the gynecology department of the Novosibirsk Regional Oncology Dispensary from 2003 to 2013 with a diagnosis of primary multiple synchronous and metachronous neoplasia with endometrial lesion it was found that the most common risk factors for this disease could be considered: overweight and obesity; late age at onset of menarche; late age of menopause; concomitant cardiovascular diseases and disorders of the endocrine metabolism.

[Microrna, evolution and cancer].

MicroRNAs are known as a posttranscriptional negative regulators of gene expression by binding to the 3'UTP of target mRNAs in cytoplasm. More than 1600 microRNAs expressed in human cells, are involved in the regulation of embryogenesis, differentiation, cell cycle, apoptosis, senescence, thus determining cell fate. Up to 60 % of protein coding genes are under their control.

[Tissue-specific expression of hormonal carcinogenesis target genes in rats treated with polycyclic aromatic hydrocarbons].

We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Treatment of rats with benzo(a)pyren (BP) or 3-methylcholantrene (MC) significantly up-regulated CYP1A1, CYP1B1 gene expression in liver, uterus and ovary, whereas alfa-naphthoflavone (alpha-NF) did not have any effect. The high level of aromatase gene (CYP19) expression was detected in ovary only.

[Remote effects of Aroclor 1254 on the rat liver microsomal monooxygenase activity in acute pancreatitis].

Constitutive activities of the liver cytochromes P450 1A1, 1A2, 2C6 and 2B1 were lower in rats with the acute experimental pancreatitis during ten days of this disease. In rats pretreated with a single dose of Arochlor 1254 on the second day of pancreatitis activities of these enzymes remained elevated to the tenth day. Thus, acute pancreatitis caused long-term suppression of microsomal monooxygenase system, whereas induction by Arochlor 1254 increased cytochromes P450 activity in both control animals and in rats with pancreatitis.

[Changes in the microsomal monooxygenase system of the rat liver in acute pancreatitis and during induction by Aroclor 1254].

The effect of Arochlor 1254 treatment of rats on activities of cytochrome P450 isoforms 1A1, 1A2, 2C6 was investigated under conditions of acute pancreatitis. Irrespectively to the scheme of Arochlor 1254 administration (before the development of pancreatitis, and at various periods after its provocation) cytochrome P450 activities were higher than in corresponding controls.