Roxadustat for anemia in patients with end-stage renal disease incident to dialysis.

Background: We evaluated the efficacy and safety of roxadustat versus epoetin alfa for the treatment of chronic kidney disease-related anemia in patients new to dialysis.

Methods: HIMALAYAS was a Phase 3, open-label, epoetin alfa-controlled trial. Eligible adults were incident to hemodialysis/peritoneal dialysis for 2 weeks to ≤4 months prior to randomization and had mean hemoglobin (Hb) ≤10.

[Prediction of mortality in patients with acute hepatic failure].

The article deals with a study of 243 patients (from 18 to 65 years old) with acute hepatic failure. Purpose of the study was to evaluate the predictive capability of severity scales APACHE III, SOFA, MODS, Child-Pugh and to identify mortality predictors in patients with acute hepatic failure. Results; The best predictive ability in patients with acute hepatic failure and multiple organ failure had APACHE III and SOFA scales.

[Hemostasis during MARS therapy and hemodiafitration in patiens with acute renal-hepatic failure].

Objective: to study the dynamics of the haemostatic system, depending on coagulopathy type and efferent therapy method (HDF, MARS) in patiens with acute renal-hepatic failure. As a complex of intensive therapy, all the patients were trated extracorporeal techniques: HDF therapy in group I (n = 121) and MARS in group 1 (n = 62). Patients were aged from 18 to 67 years.

[Replacement therapy for hepatic failure syndrome].

The results of treatment were studied in 33 patients with hepatic failure syndrome. The patients received MARS therapy or hemodiafiltration as part of intensive care. Albumin dialysis (MARS) may replace hepatic detoxifying function and it is highly effective in diminishing cytolysis in patients with hepatic failure syndrome.

[Prevalence and risk factors of the development of irritable bowel syndrome in adolescents: a population study].

Aim: To determine prevalence of irritable bowel syndrome (IBS) and associated factors in a community-based population of adolescents.

Material And Methods: 189 schoolboys and 250 schoolgirls aged 14-17 years from four randomly chosen schools of Novosibirsk participated in the study.

Results: The prevalence of IBS defined according to Rome criteria was higher in girls (24 vs 14% in boys, p = 0.