Intralesional amphotericin B in a cat with cutaneous protothecosis.

A domestic cat was presented with nodular lesions on the nose/muzzle and pinnae. Protothecosis was diagnosed through cytological and histopathological examination, and culture. Molecular identification confirmed Prototheca wickerhamii infection.

Association between breeding bulls' reactivity to humans or handling and their daily behaviour and growth.

In beef cattle, reactivity to humans or handling by humans is considered a safety issue for farmers and to impact on productivity. Several testing procedures, associated with potential risks for both humans and animals, have been developed, involving simple human approach, free animals individually handled, or restraint in handling facilities. We investigated how such tests may be related to each other and which dimensions they reveal.

Germline-Dependent Antibody Paratope States and Pairing Specific V-V Interface Dynamics.

Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 different kappa light chains paired with 4 different heavy chains. In this study, we systematically show that different heavy and light chain pairings strongly influence the paratope, interdomain interaction patterns and the relative V-V interface orientations.