Publications by authors named "L F Angel"
Background: Research indicates a high prevalence of depressive disorders in individuals with autism spectrums disorders (ASD), highlighting a need for depression screening in this population. Both depression screening tools used in the general population and tools developed specifically for individuals with ASD are used in the ASD population. Because depressive symptoms may manifest differently in individuals with ASD, it is important to establish the psychometric properties of depression instruments in individuals with ASD to determine whether and how these instruments can be applied in assessing these individuals.
View Article and Find Full Text PDFLung allograft dysbiosis associates with immune response and primary graft dysfunction.
J Heart Lung Transplant
November 2024
Article Synopsis
- Lower airway dysbiosis, characterized by an increase in specific bacteria, is linked to various severity grades of primary graft dysfunction (PGD) after lung transplantation, particularly in moderate and severe cases.
- A study involving lower airway samples from 96 lung transplant recipients showed correlations between PGD severity and elevated levels of inflammatory markers, particularly neutrophils and specific cytokines, indicating a distinct inflammatory response.
- Results suggest that microbial differences may influence host immune signaling, potentially exacerbating inflammation and contributing to PGD pathogenesis, highlighting the importance of microbial balance in lung health post-transplant.
Norms for neuropsychological tests in cognitively healthy French oldest old adults.
J Int Neuropsychol Soc
September 2024
Objective: Normal aging often leads to cognitive decline, and oldest old people, over 80 years old, have a 15% risk of developing neurodegenerative diseases. Therefore, it is important to have appropriate tools to assess cognitive function in old age. The study aimed to provide new norms for neuropsychological tests used to evaluate the cognitive abilities in people aged 80 years and older in France, focusing on the impact of education and gender differences.
View Article and Find Full Text PDFIntroduction: Mounting evidence indicates that an individual's humoral adaptive immune response plays a critical role in the setting of SARS-CoV-2 infection, and that the efficiency of the response correlates with disease severity. The relationship between the adaptive immune dynamics in the lower airways with those in the systemic circulation, and how these relate to an individual's clinical response to SARS-CoV-2 infection, are less understood and are the focus of this study.
Material And Methods: We investigated the adaptive immune response to SARS-CoV-2 in paired samples from the lower airways and blood from 27 critically ill patients during the first wave of the pandemic (median time from symptom onset to intubation 11 days).