Anxiolytic-like Effect of Chrysin on Female Zebrafish is Likely Mediated by α5 subunits of GABAA Receptors.

Chrysin (5,7-dihydroxyflavone) is a natural flavonoid with potential anxiolytic-like effects in preclinical models. Acute treatment with this molecule (0 - 10 mg/kg) produced a biphasic dose-response in the zebrafish light/dark test (LDT), with anxiolytic-like effect at low doses and anxiogenic-like effects at high doses. Chrysin (1 mg/kg) decreased anxiety-like behavior in the zebrafish novel tank test (NTT), but did not prevent the anxiogenic effects of acute stress.

Necrotizing enterocolitis causes increased ileal goblet cell loss in KO mice.

WNT2B is Wnt ligand which is able to support intestinal stem cells (ISC) in culture and support the intestinal epithelium in vivo. We have previously shown that WNT2B is critical for resistance to colitis, but not small intestinal injury, in the adult mouse. WNT2B is thought to coordinate with WNT3 in supporting ISC, and we have also shown that WNT3 expression is low in the early postnatal ileum in mice.

Network analysis of cattle movement among municipalities in Minas Gerais State, Brazil, from 2013 to 2023.

The aim of this study was to characterize the movement among municipalities in Minas Gerais state, Brazil, and to perform a network analysis based on these movements. Data on cattle movement in Minas Gerais, Brazil, from January 2013 to August 2023 were acquired from Guia de Trânsito Animal (GTA) (Animal Transit Guide), mandatory in Brazil for all livestock movements, provided by Instituto Mineiro de Agropecuária (IMA) (State Animal Health Authority). Descriptive analysis was performed, the five most common municipalities that were the origin and destination of movements were described, and the reason for transportation was assessed.

WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells.

Purpose: Histone deacetylase 6 (HDAC6) plays a critical role in tumorigenesis and tumor progression, contributing to proliferation, chemoresistance, and cell motility by regulating microtubule architecture. Despite its upregulation in melanoma tissues and cell lines, the specific biological roles of HDAC6 in melanoma are not well understood. This study aims to explore the functional effects and underlying mechanisms of WT161, a selective HDAC6 inhibitor, in melanoma cell lines.