Publications by authors named "L Escudero"
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a significant health issue worldwide, contributing to high mortality rates, and is often underdiagnosed in Spain, prompting the CARABELA-COPD initiative to improve care.
- The CARABELA-COPD initiative uses a four-phase lean methodology focusing on collaboration among various stakeholders to enhance COPD management across different healthcare settings in Spain.
- Initial results include the development of a comprehensive patient journey, identification of key improvement areas in care, and establishment of quality indicators, aiming to transform COPD management and improve patient outcomes through interdisciplinary teamwork.
The efficiency of graphene oxide functionalized with L-asparagine (GO@L-Asn) as adsorbent for crystal violet (CV) dye removal from water and wastewater was investigated. The surface and textural properties of this new nanomaterial were characterized by pH at point of zero charge, Fourier-transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, and Brunauer-Emmet-Teller technique. The main experimental variables involved in dye adsorption process were evaluated and optimized.
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- The study assessed outcomes, resource use, and costs related to Chronic Obstructive Pulmonary Disease (COPD) by analyzing a cohort of patients who visited the emergency department in 2018.
- In a sample of 2,384 COPD patients, the study found high mortality rates—23.4% within one year—and significant readmission rates, with costs totaling approximately €14.6 million.
- The findings highlight the need for specialized programs to improve care for COPD patients due to their high mortality, readmission rates, and substantial economic burden on the healthcare system.
Patients with brain metastases (BM) face a 90% mortality rate within one year of diagnosis and the current standard of care is palliative. Targeting BM-initiating cells (BMICs) is a feasible strategy to treat BM, but druggable targets are limited. Here, we apply Connectivity Map analysis to lung-, breast-, and melanoma-pre-metastatic BMIC gene expression signatures and identify inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo GTP synthesis pathway, as a target for BM.
View Article and Find Full Text PDFExperimental design and multiple response optimization of batch leaching tests of volcanic ashes.
Environ Sci Pollut Res Int
October 2024
Volcanic eruptions can release large amounts of tephra, lava, and gases, drawing attention due to their magnitude, energy, and impact on life and the environment. Among the most documented and sometimes dramatic effects of volcanic ashes are those linked to the input of diverse elements in the environment, which are released as a consequence of ash weathering. Laboratory studies have been conducted to investigate and predict the environmental input of chemical elements from volcanic ashes.
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