System-based insights into parasitological and clinical treatment failure in Chagas disease.

Infectious disease treatment success requires symptom resolution (clinical treatment success), which often but not always involves pathogen clearance. Both of these treatment goals face disease-specific and general challenges. In this review, we summarize the current state of knowledge in mechanisms of clinical and parasitological treatment failure in the context of Chagas disease, a neglected tropical disease causing cardiac and gastrointestinal symptoms.

Managing cardiovascular disease in pregnant people: Defining the pregnancy heart team.

Cardiovascular disease is a leading cause of morbidity and mortality for pregnant patients. A significant portion of cardiac morbidity and mortality is preventable and related to poor or delayed recognition of clinical warning signs and oversights in management. The establishment of pregnancy heart teams facilitates multidisciplinary planning to improve management of people with cardiovascular disease.

Placental Pathology and Blood Pressure at Age 7: A Longitudinal Discordant Twin Analysis.

Background: Evidence suggests that the intrauterine environment shapes offspring cardiovascular disease risk. Although placental dysfunction may be an important pathophysiologic pathway, numerous parental and pregnancy characteristics that influence offspring blood pressure are strong confounders of the mechanistic role of the placenta in observational analyses of singletons. Therefore, we leverage twin- and sibling-based comparison designs to determine whether placental pathology is associated with offspring blood pressure at age 7 while mitigating major sources of confounding.

Simultaneous, Non-Contact and Motion-Based Monitoring of Respiratory Rate in Sheep Under Experimental Condition Using Visible and Near-Infrared Videos.

The validation of methods for understanding the effects of many diseases and treatments requires the use of animal models in translational research. In this context, sheep have been employed extensively in scientific studies. However, the imposition of experimental conditions upon these animals may result in the experience of discomfort, pain, and stress.

Incidence and Risk Factors for Sport-Related Concussion in Female Youth Athletes Participating in Contact and Collision Invasion Sports: A Systematic Review.

Background: The incidence and risk factors for sport-related concussion (SRC) associated with contact and collision invasion sports (CCIS) in female youth are unclear.

Objectives: This systematic review aimed to identify (i) the incidence of and (ii) risk factors for SRC in female youth athletes playing CCIS.

Methods: A systematic search of PubMed, CINAHL, Embase, SPORTDiscus and ProQuest to 8 May, 2024 was conducted.