Publications by authors named "L Er"
This study enrolled 10 patients diagnosed with premalignant lesions and early-stage gastric cardia adenocarcinoma (GCA), confirmed through endoscopic examination. These patients were subjected to next-generation sequencing (NGS) using a customized 1123-gene panel to identify genetic alterations and signaling pathways. The results were compared to stage IIB to IV GCA samples from the cancer genome atlas (TCGA) and a cohort of Hong Kong patients.
View Article and Find Full Text PDFBackground: Patients with primary aldosteronism (PA) exhibit a high prevalence of diabetes mellitus (DM). However, the relationship between visceral adipose tissue (VAT) and new-onset diabetes mellitus (NODM) in PA patients remains unclear.
Objectives: To explore the association between VAT and the risk of NODM in PA patients.
Article Synopsis
- * This research analyzed data from 1912 patients over an average of 6.8 years, discovering that corticosteroids did not significantly increase cardiovascular risk, but higher doses of calcineurin inhibitors and certain antimetabolites were linked to greater risks.
- * The study highlights that different immunosuppressive treatments carry varying cardiovascular risks, which should be a crucial factor in choosing therapy for patients with glomerular disease.
Geranylgeraniol: Bio-based platform for teprenone, menaquinone-4, and α-tocotrienol synthesis.
Bioresour Technol
November 2024
Article Synopsis
- * This study introduces a new strategy that uses a chemosynthesis-like method to emphasize the value of biobased intermediates, specifically focusing on geranylgeraniol (GGOH) production.
- * Through advanced metabolic engineering and a novel yeast strain, researchers achieved significant GGOH production, which led to the semi-synthesis of several pharmaceuticals, suggesting new possibilities for industrial production improvements and innovations.
Article Synopsis
- * In a study involving 947 children with IgAN, the revised tool outperformed the original in terms of model fit and predictive accuracy for 4-year outcomes, showing enhanced calibration and statistical values.
- * The findings indicated that kidney function (eGFR) trajectories were non-linear, with higher-risk children showing a faster decline, suggesting that the updated prediction should be used for ongoing risk assessment after one or two years following biopsy.