Publications by authors named "L Elkrief"
Article Synopsis
- A systematic review and meta-analysis were conducted to evaluate the effectiveness and safety of naltrexone as a treatment for amphetamine-type stimulant use disorder (ATSUD) using data from several medical databases.
- Five randomized placebo-controlled trials involving 419 participants were analyzed, showing no significant difference in outcomes such as reductions in stimulant use, treatment retention, or cravings between naltrexone and placebo groups.
- The study concluded that there is insufficient evidence to support the use of naltrexone alone for treating ATSUD, highlighting the need for more research to find effective pharmacotherapies alongside psychosocial treatments.
Management of portal vein thrombosis in cirrhosis - Authors' reply.
Lancet Gastroenterol Hepatol
December 2024
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a dimensional framework for psychopathology advanced by a consortium of nosologists. In the HiTOP system, psychopathology is grouped hierarchically from super-spectra, spectra, and subfactors at the upper levels to homogeneous symptom components and maladaptive traits and their constituent symptoms, and maladaptive behaviors at the lower levels. HiTOP has the potential to improve clinical outcomes by planning treatment based on symptom severity rather than heterogeneous diagnoses, targeting treatment across different levels of the hierarchy, and assessing distress and impairment separately from the observed symptom profile.
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- Relapse after stopping immunosuppression treatment is common in Autoimmune Hepatitis (AIH) patients, and there's a need for better non-invasive biomarkers to predict this risk.
- The study analyzed blood samples from 58 active AIH patients, 56 in remission, and 31 with NASH, focusing on the levels of activated T cell subsets and the cytokine BAFF.
- Results showed that increased frequencies of certain activated T cells and high BAFF levels in remission patients were strongly linked to a higher chance of relapse after treatment withdrawal, suggesting these could serve as useful biomarkers for monitoring AIH.
Article Synopsis
- Alcohol-related liver disease (ALD) affects about 30% of heavy drinkers, characterized by liver damage including steatosis, fibrosis, and steatohepatitis.
- The study investigated the connection between genetic variants of keratins 8 and 18 (KRT8/18) and histological features of ALD in 106 severe cases, finding significant links to specific genetic variants.
- Elevated levels of KRT18 fragments were associated with certain KRT18 variants and alcoholic hepatitis, indicating that these genetic factors may influence the severity and prognosis of ALD.