Publications by authors named "L Eldredge"
Article Synopsis
- The study focused on ventilator-dependent infants and children with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) to assess their health outcomes.
- Approximately 60% of the 154 subjects had pulmonary hypertension, with many requiring specific medications; those with PH tended to transition to home ventilation and discharge at older ages.
- Despite the challenges, most subjects improved over time, successfully weaning off oxygen and ventilators by age 5, with a low mortality rate after discharge.
Article Synopsis
- Lung macrophages are important in health and disease, with their function influenced by biological sex, which can lead to different health outcomes in conditions like bronchopulmonary dysplasia (BPD).
- Research investigated how the transcriptional state of alveolar macrophages in neonatal mice is affected by hyperoxia-induced lung injury, revealing that injury reduces macrophage levels initially but allows for recovery in both sexes.
- Analysis showed that female macrophages enriched pathways related to DNA damage and interferon signaling, while male macrophages showed enriched glucose metabolism pathways; similar trends were observed in human premature neonates.
Multidisciplinary bronchopulmonary dysplasia (BPD) programs provide improved and consistent medical management, care of the developing infant, family support, and smoother transitions in care resulting in improved survival, pulmonary, and extra-pulmonary outcomes. This review summarizes the benefits of interdisciplinary BPD management, as well as strategies for initial programmatic development, program growth, and maintenance at centers across the United States factoring in institutional, provider, and parent reported goals that were derived from a consensus conference on BPD management.
View Article and Find Full Text PDFObjective: Routine blood gas measurements are common in infants with severe bronchopulmonary dysplasia (sBPD) and are a noxious stimulus. We developed a guideline-driven approach to evaluate the care of infants with sBPD without routine blood gas sampling in the chronic phase of NICU care (after diagnosis at 36 weeks PMA).
Study Design: We examined blood gas utilization and outcomes in our sBPD inpatient care unit using data collected between 2014 and 2020.
Respiratory disease is one of the most common complications of preterm birth. Survivors of prematurity have increased risks of morbidities and mortalities independent of prematurity, and frequently require multiple medications, home respiratory support, and subspecialty care to maintain health. Although advances in neonatal and pulmonary care have improved overall survival, earlier gestational age, lower birth weight, chorioamnionitis and late onset sepsis continue to be major factors in the development of bronchopulmonary dysplasia.
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