Publications by authors named "L Edelstein"
The aim of this study is to investigate whether the dorsal claustrum receives afferent input from the intralaminar thalamic nuclei - centromedian nucleus, central lateral nucleus and paracentral nucleus. The intralaminar thalamic nuclei of eight cats were electrolytically lesioned. We obtained samples from the dorsal claustrum for electron microscopic analysis from the second to the seventh post-procedural day.
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- Long noncoding RNAs (lncRNAs) play a significant but not fully understood role in the regulation of inflammation, particularly in inflammatory bowel disease (IBD).
- Researchers used RNA-sequencing data from IBD patients to identify gene modules where lncRNAs are coexpressed with protein-coding genes, some of which correlate with disease severity and immune responses.
- The study highlighted a specific lncRNA, IRF1-AS1, linked to a response in inflammatory cytokines and identified other lncRNAs that could affect inflammation in response to stimuli, suggesting new pathways for IBD treatment.
Background: Human and mouse platelets both express protease-activated receptor (PAR) 4 but sequence alignment reveals differences in several functional domains. These differences may result in functional disparities between the receptors which make it difficult to translate PAR4 studies using mice to human platelet physiology.
Objectives: To generate transgenic mice that express human, but not mouse, PAR4 and directly compare human and mouse PAR4 function in the same platelet environment.
PCTP (phosphatidylcholine transfer protein) was discovered recently to regulate aggregation of human platelets stimulated with PAR4 activating peptide (PAR4AP). However, the role of PCTP following thrombin stimulation, the mechanisms by which PCTP contributes to platelet activation, and the role of PCTP with other receptors remained unknown. As mouse platelets do not express PCTP, we treated human platelets with various agonists in the presence of the specific PCTP inhibitor A1.
View Article and Find Full Text PDFArtificial intelligence (AI) is defined as the ability of machines to perform tasks that are usually associated with intelligent beings. Argument and debate are fundamental capabilities of human intelligence, essential for a wide range of human activities, and common to all human societies. The development of computational argumentation technologies is therefore an important emerging discipline in AI research.
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