Publications by authors named "L Eccleston"
Defense responses in plants are based on complex biochemical processes. Systemic acquired resistance (SAR) helps to fight infections by (hemi-)biotrophic pathogens. One important signaling molecule in SAR is pipecolic acid (Pip), accumulation of which is dependent on the aminotransferase ALD1 in Arabidopsis.
View Article and Find Full Text PDFPlants host a multipart immune signalling network to ward off pathogens. Pathogen attack upon plant tissues can often lead to an amplified state of (induced) defence against subsequent infections in distal tissues; this is known as systemic acquired resistance (SAR). The interaction of plants with beneficial microbes of the rhizosphere microbiome can also lead to an induced resistance in above-ground plant tissues, known as induced systemic resistance.
View Article and Find Full Text PDFIntroduction: Amlodipine overdoses have significant cardiac toxicity and are difficult to treat. Methylene blue has potential as a treatment for overdoses.
Methods: A randomized controlled study of methylene blue as a treatment for amlodipine toxicity was conducted in C57Bl/6 mice.
Article Synopsis
- Venezuelan equine encephalitis virus (VEEV) is a highly infectious virus recognized as a potential bio-terrorism threat, and there is currently no effective licensed vaccine available.
- Researchers inactivated an attenuated strain of VEEV using a chemical called 1,5-iodonaphthyl azide (INA) and tested its effectiveness against a virulent form of the virus.
- The study found that intramuscular vaccination with the INA-inactivated version (INA-iV3526) resulted in complete protection from the aerosolized virulent VEEV, indicating its potential as a viable vaccine candidate.
Article Synopsis
- Eastern equine encephalitis virus (EEEV) is a highly fatal virus with no current vaccines or treatments, making research on its effects critical for future developments.
- In a study, female BALB/c mice were infected with EEEV using three different methods—intranasal, aerosol, and subcutaneous—to analyze the virus's impact on brain tissue and pathology.
- Results indicate that EEEV can enter the brain faster through the olfactory system when mice are infected via aerosol or intranasal routes but takes longer through the subcutaneous method, highlighting different pathways of infection and the need for targeted therapeutic research.