NiO-Based Aerogels-Unexpected Formation of Metallic Nickel Nanoparticles during Supercritical Drying Process.

The aim of the study is to investigate the influence of the solvents applied both in sol-gel process and for supercritical drying (SCD) on NiO aerogels' properties. NiO aerogels were synthesized using methanol and 2-methoxy-ethanol (MeGl) as sol solvents. SCD was performed using iso-propanol, methanol and tert-butyl-methyl ether as supercritical fluids.

3D Neuronal Cell Culture Modeling Based on Highly Porous Ultra-High Molecular Weight Polyethylene.

Cell culturing methods in its classical 2D approach have limitations associated with altered cell morphology, gene expression patterns, migration, cell cycle and proliferation. Moreover, high throughput drug screening is mainly performed on 2D cell cultures which are physiologically far from proper cell functions resulting in inadequate hit-compounds which subsequently fail. A shift to 3D culturing protocols could solve issues with altered cell biochemistry and signaling which would lead to a proper recapitulation of physiological conditions in test systems.

[The immunohistochemical features of ovarian serous adenocarcinoma cells, which determine a disease course and survival rates in patients].

Objective: To study a relationship of survival rates to the expression of major genes (p53, PTEN, COX2, pRb and others) involved in the pathogenesis of ovarian cancer.

Subjects And Methods: The trial enrolled 23 patients with Stages III-IV ovarian serous adenocarcinoma. Of them, 11 patients showed a long overall survival (median 50 ± 2.