Publications by authors named "L E Williams"
Article Synopsis
- Pseudomonas aeruginosa, when losing DNA mismatch repair (MMR), becomes a hypermutator, leading to high rates of multidrug resistance (MDR), especially after exposure to antibiotics.
- Hypermutated MMR-deficient P. aeruginosa has a specific mutational signature and quickly develops MDR through shared resistance mechanisms across different drug classes.
- Analyzing mutational signatures of P. aeruginosa in patients shows many MMR-deficient strains are already MDR or likely to become resistant, indicating that this analysis could be a valuable diagnostic tool for predicting and managing MDR in clinical settings.
Study Objectives: Physicians-in-training (residents, fellows) and Advanced Practice Providers (APPs) receive limited education on sleep disorders, including obstructive sleep apnea (OSA). They often assess patients first. We aimed to understand their views on OSA and screening for OSA in the perioperative period.
View Article and Find Full Text PDFRunners often reduce their pace during inclined running to maintain a constant metabolic workload, known as iso-efficiency speed (a speed-incline combination with the same metabolic intensity as level running). This study investigates changes in lower extremity (LE) joint work profiles when running on an incline at iso-efficiency speed. Eleven collegiate distance runners completed a treadmill running task under three conditions (0%, 4%, and 8% incline).
View Article and Find Full Text PDFThe gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease (IBD). While research has focused on the bacterial microbiome, recent studies have shifted towards host genetics and host-fungal interactions. The mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune regulation.
View Article and Find Full Text PDFObjective: To characterize the perioperative complications after ablative and reconstructive surgery in patients with head and neck cancer (HNC) based on race.
Methods: We conducted a retrospective study of the 2015-2020 National Surgical Quality Improvement Program Database. We compared the perioperative outcomes between White, Asian, Black, Native Hawaiian or Pacific Islander, and American Indian or Alaskan Native patients with bivariate analysis.