Publications by authors named "L E Schanberg"
Objective: The objective of this study was to evaluate the preliminary effectiveness of an electronic pill bottle with automated reminders on hydroxychloroquine (HCQ) adherence in children with pediatric systemic lupus erythematosus (pSLE).
Methods: This was a self-controlled, open label, direct-to-family pilot trial. Children with pSLE treated with HCQ were recruited from the Childhood Arthritis and Rheumatology Research Alliance Registry.
Article Synopsis
- The study investigates meaningful score differences (MSDs) for PROMIS Pediatric measures in children with juvenile idiopathic arthritis (JIA) or systemic lupus erythematosus (SLE), assessing how well various external anchors can help interpret these scores.
- Researchers utilized longitudinal data from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and evaluated candidate anchors like global impressions of change from patients, parents, and clinicians based on specific criteria.
- Results indicated that many candidate anchors did not meet quality standards, and the choice of anchor significantly influenced the calculated MSD values, highlighting the importance of selecting high-quality anchors for accurate score interpretations in pediatric populations.
Article Synopsis
- Some experts and patients worked together to create a set of important data to help study childhood lupus, a disease that affects children.
- They made two datasets: a Core Dataset with 46 necessary items and an Expanded Dataset with 26 extra items, to help gather more information.
- This new information will help researchers around the world study childhood lupus better by using the same important facts and details.
Racial Disparities and Achievement of the Low Lupus Disease Activity State: A CARRA Registry Study.
Arthritis Care Res (Hoboken)
January 2025
Article Synopsis
- * Among 540 children studied, Black children were found to have significantly lower chances of reaching LLDAS and higher disease activity compared to their White counterparts, with 41% of Black children living in the most disadvantaged neighborhoods.
- * The findings suggest that addressing underlying issues related to race and neighborhood socioeconomic status is critical for improving treatment outcomes and reducing health disparities in cSLE.
Objective: Despite treatment advances, pain remains a serious problem for many children with juvenile idiopathic arthritis (JIA). To better understand pain in children with JIA and identify potentially modifiable factors, this study evaluated Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Pain Interference (PI) and its relationships with other pain measures and demographic, clinical, psychosocial, and functional variables.
Methods: This cross-sectional, observational, multicenter study used descriptive statistics and a mix of bivariate and multivariable analyses to describe PI and characterize relationships with other measures and variables.