Histopathological, ultrastructural, and biochemical traits of apoptosis induced by peroxisomicine A1 (toxin T-514) from in kidney and lung.

Peroxisomicine A1 (PA1) is a toxin isolated from the genus plants whose target organs are the liver, kidney, and lung. studies demonstrated the induction of apoptosis by PA1 in cancer cell lines, and in the liver. Apoptosis has a wide range of morphological features such as cell shrinkage, plasma membrane blistering, loss of microvilli, cytoplasm, and chromatin condensation, internucleosomal DNA fragmentation, and formation of apoptotic bodies that are phagocytized by resident macrophages or nearby cells.

Short- and Long-Term Exposure to Heat Stress Differently Affect Performance, Blood Parameters, and Integrity of Intestinal Epithelia of Growing Pigs.

The effect of short- and long-term exposure to heat stress (HS) was analyzed on blood components, performance, and intestinal epithelium integrity of pigs. Eighteen pigs (36.0 ± 3.

Distribution of M1 and M2 macrophages in cerebral granulomas caused by Encephalitozoon cuniculi.

Encephalitozoon cuniculi spores cause severe granulomatous inflammation in the brain where mononuclear cells and macrophages infiltrate. Here, we orally infected New Zealand white rabbits with 1 × 10E. cuniculi viable spores to study the recruitment and localization of macrophages in brain granulomas.

Mixed Pneumoconiosis Associated with Diffuse Pulmonary Ossification in Wild Coyotes (Canis latrans).

Mixed pneumoconiosis is a pulmonary disease associated with several inhaled mineral irritants. Dust was found in the alveolar macrophages, alveolar and bronchial walls and pulmonary interstitial tissue of two female coyotes (Canis latrans). The dust contained large amounts of silica, coal, iron and copper particles, which were associated with severe pulmonary disease.

Analysis of the Anti-Inflammatory Capacity of Bone Broth in a Murine Model of Ulcerative Colitis.

Nutritional deficiencies are one of the main triggers for the development of gastrointestinal diseases, such as ulcerative colitis (UC). Therefore, the objective of the present work consisted of determining the nutrients present in the bone broth (BB) and evaluating their anti-inflammatory properties in a murine model of UC, induced by intrarectal administration of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS), and acetic acid (AcOH). The BB was prepared from the femur of bovine cattle and cooked in distilled water for 8 h at 100 ± 2 °C.