Alternate definitions of adverse pathology to predict a very high risk of metastasis in men with intermediate- and low-risk prostate cancer.

Background: Adverse pathology (AP) is often used as an intermediate end point for long-term outcomes in men with prostate cancer (PCa) who are active surveillance candidates. The association between a commonly used AP definition and long-term outcomes was tested, which identified definitions more strongly linked to a high risk of metastasis.

Methods: Data were reviewed from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing radical prostatectomy (RP) from 1988 to 2020 at nine Veterans Affairs hospitals.

Deleterious Effects of Yoyo Dieting and Resistant Starch on Gastrointestinal Morphology.

Background: Obesity is associated with structural deterioration in the gut. Yoyo dieting, which refers to repeated phases of dieting and non-dieting periods leading to cyclic weight loss and regain, is a common occurrence in individuals with obesity. However, there is limited evidence on how gut structures are affected in yoyo dieting.

Localisation of the relaxin-family peptide 3 receptor to enteroendocrine cells of the intestine in RXFP3-Cre/tdTomato mice.

The relaxin-family peptide 3 receptor (RXFP3) and its native ligand, relaxin-3, are expressed in specific populations of brain neurons, and research on this system has focused on its role in the central nervous system. However, some studies have indicated that relaxin-3 and RXFP3 are also expressed in peripheral organs, including the gut. In this study, we characterised the identity of RXFP3-expressing cells in the gastrointestinal tract, using RXFP3-Cre/tdTomato reporter mice.

Modeling voice production and self-perception in noise: Understanding the Lombard effect in non-phonotraumatic vocal hyperfunctiona).

The sensorimotor adaptation process is crucial for maintaining oral communication. Recent studies have shown that individuals with non-phonotraumatic vocal hyperfunction (NPVH) experience difficulties in sensorimotor adaptation when speaking in noise (known as the Lombard effect). However, the role of auditory and somatosensory feedback in the dynamics of adaptation to speaking in noise is still unclear.

Stressors for farmworker parents during wildfire season.

Background: The severity of wildfire seasons amplify stressors that farmworker families in the Pacific Northwest face as they balance childcare, work, and personal wellbeing. A lack of safe and attainable childcare has been a challenge for farmworker parents since before the Covid-19 pandemic and is of particular concern during wildfire season when parents must weigh the risks and benefits of leaving children at home, taking them to work, or sending them to childcare. This study describes how stressors of balancing childcare, work, and concerns about children's exposure to smoke during wildfire season impact the wellbeing and workplace absenteeism and presenteeism for farmworker parents.