[The specific features of the course of pulmonary tuberculosis in young Tuvinians in relation to some antigens of the HLA complex].

The study covered 127 new-onset pulmonary tuberculosis patients aged 18-30 years. Disseminated, focal, and infiltrative tuberculosis were found in 10.2, 22, 46.

[Population-based epidemiological study of pulmonary tuberculosis in a number of rural regions of Tatarstan].

The paper presents the results of a population-based, geneticoepidemiological, and immunological study conducted in two regions of Tatarstan. The population-based risks for tuberculosis were established for males and females. Based on the population and family data, the authors calculated the genetic liability to tuberculosis, namely hereditability that is in the range of 0.

[Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva].

Polymerase chain reaction-RFLP was used to distribute two polymorphic markers (SNP) PARK2-e01 (-697) and rs1333955 located at the common promoter site of the PARK2 and PACRG genes in order to reveal assumed associations with the incidence of pulmonary tuberculosis in the Barum-Khemchiksky and Ovyursky Districts of the Republic of Tyva. No significant differences were found in the frequencies of these two polymorphic markers between the groups of patients with tuberculosis and healthy individuals, residing in the above districts, and between the total control samples from both districts. The total group of patients with tuberculosis from the two districts from the Republic of Tyva showed a significant surplus of heterozygotes in both study markers, as compared with the group of healthy individuals, which was also observed for the marker rs1333955 in the Barum-Khemchksky District alone.

[Genetic HLA markers associated with pulmonary tuberculosis in the Barum-Khemchiksky District, Republic of Tyva].

Detection of the genetic markers determining a predisposition to pulmonary tuberculosis is a necessary condition for the warranted formation of risk groups in the populations. On this basis, the authors used immunogenetic studies to examine 60 patients with pulmonary tuberculosis and 96 healthy individuals of Tuvinian nationality, who lived in the Barum-Khemchiksky District, Republic of Tyva. The microlymphocytotoxic test was used to determine class I HLA antigens and polymerase chain reaction was employed to reveal the specificity of class II HLA-DRB1 gene.

[Effect of use of bone marrow cells in therapy for experimental tuberculosis].

The authors studied the efficiency of use of bone marrow cells in the treatment of experimental tuberculosis. Bone marrow cell transplantation to H37Rv tuberculosis-infected H37Rv mice was shown to prolong the life span in the animals as compared to untreated animals. Examination of humoral immunity indicated that administration of allogenic bone marrow cells resulted in the nonspecific polyisotypic stimulation of antituberculosis antibodies, which is essential in producing the protective humoral background.