Publications by authors named "L E Orr"
Background: The essential amino acid leucine (LEU) plays a crucial role in promoting resistance-training adaptations. Dileucine (DILEU), a LEU-LEU dipeptide, increases MPS rates, however its impact on resistance training outcomes remains unexplored. This study assessed the effects of DILEU supplementation on resistance training adaptations.
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- Linking mothers to their newborns in health records helps assess the effects of policies and treatments on health over generations, but privacy issues limit access to traditional identifiers.
- A new scalable linking algorithm that uses Medicaid claims data without direct identifiers successfully connects mothers and infants while maintaining privacy.
- The algorithm linked 11.68 million mother-infant pairs across 50 states over 19 years, enabling important research on health determinants and the impact of public policy on families.
While there are women represented in some notable positions within the UK Defence Medical Services (DMS), the challenges and barriers to successful female progression have not disappeared. The DMS needs highly talented, motivated doctors working to support operations, yet we struggle to recruit and retain female personnel. This is in clear contrast to the increased proportion of female personnel working within the civilian medical workforce.
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- The study investigates the effectiveness of whole blood therapy versus component therapy in traumatic care within a rural Level II trauma center, focusing on factors such as wastage rates and patient mortality.
- It found that whole blood therapy resulted in significantly lower mortality rates (8%) compared to component therapy (29%) and reduced blood wastage from 43.4% in 2021 to 38.7% in 2022.
- Overall, implementing a whole blood program improved patient outcomes and was positively received by staff for its streamlined administration process.
14-3-3 proteins have a unique ability to bind and sequester a multitude of diverse phosphorylated signaling proteins and transcription factors. Many previous studies have shown that interactions of 14-3-3 with specific phosphorylated substrate proteins can be enhanced through small-molecule natural products or fully synthetic molecular glue interactions. However, enhancing 14-3-3 interactions with both therapeutically intractable transcription factor substrates and potential neo-substrates to sequester and inhibit their function remains elusive.
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