Publications by authors named "L E McCallum"
Renal ischaemia due to renal artery stenosis produces two differing responses - a juxtaglomerular hypertensive response and cortical renal dysfunction. The reversibility of renal impairment is not predictable, and thus renal revascularisation is controversial. This study aims to test the hypothesis that the hypertensive response to renal ischaemia reflects viable renal parenchyma, and thus could be used to predict the recovery in renal function.
View Article and Find Full Text PDFObjective: To use the job demands-resources model of occupational stress to quantify and explain the impact of working in critical care during the COVID-19 pandemic on nurses and their employing organisation.
Design: Two-phase mixed methods: a cross-sectional survey (January 2021-March 2022), with comparator baseline data from April to October 2018 (critical care nurses only), and semistructured interviews.
Participants: Critical care nurses ( = 461) and nurses redeployed to critical care ( = 200) who worked in the United Kingdom National Health Service (primarily Scotland) between January 2021 and March 2022.
d-limonene suppresses RANKL-induced osteoclast differentiation and promotes osteoblast activity in vitro.
Biosci Biotechnol Biochem
January 2025
Article Synopsis
- Osteoporosis treatments are usually implemented after fractures occur, so finding preventative methods to lower fracture risk is important.
- D-limonene, a natural compound found in citrus fruits, has shown potential in promoting bone health by enhancing osteoblast activity and suppressing osteoclast formation, largely due to its effects on NFκB.
- The study indicates that limonene not only supports the development of bone-forming cells but also decreases factors that lead to bone loss, suggesting it could be a useful supplement alongside existing osteoporosis treatments.
Article Synopsis
- * An observational study of 74,372 pwMS over 5 years found that 9% had deficient and 18% had inadequate vitamin D levels, both associated with a higher incidence of major adverse cardiovascular events (MACE).
- * Vitamin D supplementation (cholecalciferol) did not reduce the elevated CVD risk in pwMS with deficient or inadequate vitamin D levels compared to those with adequate levels.
Objective: Adverse birth outcomes and the maternal severity of influenza in pregnancy are well documented but information on pertussis is limited.
Design: Population-based linkage data were collected during 2001-2016.
Setting: New South Wales, Australia.