Publications by authors named "L E Krahn"
Idiopathic hypersomnia typically is a chronic and potentially debilitating neurologic sleep disorder, and is characterized by excessive daytime sleepiness. In addition to excessive daytime sleepiness, idiopathic hypersomnia symptoms can include severe sleep inertia; long, unrefreshing naps; long sleep time; and cognitive dysfunction. Patients with idiopathic hypersomnia may experience a significant impact on their quality of life, work or school performance, earnings, employment, and overall health.
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- - The study aimed to assess the feasibility and acceptability of a smartphone app designed to enhance adherence to positive airway pressure (PAP) therapy among patients newly diagnosed with obstructive sleep apnea (OSA).
- - In a randomized controlled trial involving 87 participants, researchers measured app engagement, retention rates, and patient feedback to evaluate the app's effectiveness compared to standard care and activity monitoring.
- - Results showed that the app was both feasible and acceptable, with high PAP usage reported in both groups, but no significant differences in adherence or clinical outcomes were found between the app users and the control group.
Introduction: Immediate-release sodium oxybate (SXB) has been Food and Drug Administration (FDA)-approved to treat narcolepsy since 2002; in 2020, a mixed-salt oxybates formulation was also approved. Both are taken at bedtime with a second dose taken 2.5-4 h later.
View Article and Find Full Text PDFStudy Objectives: To evaluate for potential interactions between magnetic positive airway pressure (mPAP) masks and cardiac implantable electronic devices (CIEDs) for patients with sleep apnea.
Methods: Adult patients with a CIED who used an mPAP mask were recruited from our sleep clinic to undergo a safety visit at our pacemaker clinic. We tested whether the mPAP interacted with the implanted device at home during normal use and in the clinic during simulated normal use and with direct contact.
Objective/background: Home sleep apnea tests utilizing peripheral arterial tone (PAT HSAT) detect sleep disordered breathing by measuring various physiologic measures including changes in arterial volume in the finger. Validation tests comparing PAT HSAT to simultaneous polysomnography (PSG) have demonstrated a high correlation. Alcohol increases peripheral vasodilation, which may alter arterial tone in the finger.
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