Publications by authors named "L E Kohn"
Type 1 Diabetes Mellitus (T1D) is an autoimmune disease caused by unremitting immune attack on pancreas insulin-producing beta cells. Persistence of the autoimmune response is mediated by TCF1+ Ly108+ progenitor CD8+ T (T) cells, a stem-like population that gives rise to exhausted effectors with limited cytolytic function in chronic virus infection and cancer. What paradoxically drives T conversion to highly cytolytic effectors in T1D, however, remains unclear.
View Article and Find Full Text PDFLinear enamel hypoplasias (LEHs) are development defects appearing as lines or grooves on enamel surfaces. Forming when physiological stressors disrupt developing teeth, LEHs provide retrospective insight into stress experienced in early development. Here, LEHs in Cayo Santiago rhesus macaques (Macaca mulatta) were observed with respect to decade of birth, whether an individual was transferred from the free-ranging colony to the captive facility during probable crown formation periods, and matriline of birth.
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- This study investigates the connection between gut bacteria, specifically oral pathogens, and colorectal cancer (CRC), highlighting the role of Parvimonas micra and Fusobacterium nucleatum.
- The research analyzed fecal samples from 275 CRC patients and 95 healthy controls using 16S rRNA sequencing, revealing significant differences in microbial composition linked to tumor location and microsatellite instability (MSI).
- Findings indicate that certain bacteria like P. micra and F. nucleatum are more prevalent in CRC patients, suggesting their potential role in the disease's development and the need for further research on bacterial interactions in CRC progression.
Article Synopsis
- Acne fulminans (AF) is a severe, inflammatory type of acne that typically appears in adolescents, featuring painful nodules and potentially leading to serious skin lesions and systemic symptoms like fever and joint pain.
- The exact cause of AF is not well understood, but it may be linked to certain medications and often arises in teens beginning isotretinoin treatment.
- Effective treatment generally involves a combination of prednisone and isotretinoin, with an emphasis on early diagnosis to reduce both immediate symptoms and the risk of permanent scarring; further research is needed to improve management strategies.