Publications by authors named "L E Kaufman"
Background: Weekend hospital discharges are often associated with reduced staffing, potentially impacting the quality of patient care. We studied the effects of weekend discharge after liver transplantation (LT) on early readmission rates, overall survival (OS), and graft survival (GS).
Method: We analyzed data from the Ohio State University Wexner Medical Center database (January 2016 to December 2023).
This study characterizes the influence of self-assembly conditions on the aggregation pathway and resulting photophysical properties of one-dimensional aggregates of the simple imide-substituted perylene diimide, N, N'-didodecyl-3,4,9,10-perylenedicarboximide (ddPDI). We show that ddPDI, which has symmetric alkyl chains at the imide positions, assembles into fibers with distinct morphology, emission spectra, and temperature-dependent behavior as a function of preparation conditions. In all conditions explored, aggregates are one-dimensional; however, assembly conditions can bias formation to either J-like or H-like aggregates.
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- - The study investigates how certain mutations in the p53 protein can lead to increased cancer cell invasion, contradicting previous views on mutant p53's role in cancer progression.
- - Researchers found that mutant p53 enhances the ability of cancer cells to invade their surroundings by modulating the RhoA/ROCK signaling pathway and affecting the organization of the extracellular matrix (ECM).
- - The findings suggest that the invasive effects of mutant p53 are influenced not just by the cells themselves but also by the mechanical properties of the ECM, highlighting the complex interactions during cancer metastasis.
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- Ovulation induction for IVF can lead to increased thrombosis risks in patients with antiphospholipid autoantibodies (aPLs) or antiphospholipid syndrome (APS), but the effectiveness of alternative natural cycles is unclear.
- A study analyzed 121 IVF cycles in women with aPLs or APS, comparing stimulated cycles with anticoagulant treatment to natural and modified natural cycles.
- Results showed that stimulated cycles had significantly lower cancellation rates and higher successful pregnancy outcomes, with no adverse thrombotic events reported, indicating that stimulation can be safely performed in these patients.
Dynamic heterogeneity in glassy systems has typically been characterized at the single-molecule level by extracting rotational relaxation time scales from linear dichroism (LD) collected via two orthogonally polarized channels. However, in such measurements, localization precision is diminished due to photons lost relative to collection in a single detection channel. This poses challenges in characterizing rotational and translational dynamics simultaneously, as translational measurements require high localization precision.
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