A comparison of the effect of nitroparacetamol and paracetamol on liver injury.

Paracetamol (5 mmol kg(-1), i.p.) caused liver damage in rats as indicated by increased plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glutamate dehydrogenase (GDH) activities.

Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.

Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. Following i.p.