How Should Professional Resistance Be Integrated Into Conceptions of Professional Accountability?

As more health professions students, trainees, and clinicians engage in acts of professional resistance, professional accountability is needed when acts of resistance influence patient care. This article suggests standards that can help distinguish between professional and nonprofessional resistance and prioritize minimizing harm and injustice to patients.

Empowering Stigmatized Voices: Cocreating a Curriculum on Pain and Opioid Use Disorder With Patient Partners.

Purpose: This study explores the partnership experiences of patient and health care professional (HCP) subject matter experts (SMEs) in cocreating educational content and examines their reflections on how to better support educational partnerships in future initiatives.

Method: In this qualitative, exploratory study, semistructured interviews of patient and HCP SMEs were conducted between February and August 2022. Interviews were conducted with videoconferencing software, audio recorded, and transcribed verbatim.

Xylazine: An emerging threat in obstetrics.

Xylazine, an alpha-adrenergic agent, is a common adulterant in the non-prescribed opioid supply. It has multiplicative sedative effects when used with opioids and these effects can negatively impact pregnancy. Given that the opioid epidemic in Canada is not abating and continues to evolve, cases of xylazine exposure during pregnancy are beginning to present in obstetrical units and emergency departments.

Chemoproteomic Profiling of for Characterization of Anti-fungal Kinase Inhibitors.

is a growing health concern as the leading causal agent of systemic candidiasis, a life-threatening fungal infection with a mortality rate of ~40% despite best available therapy. Yck2, a fungal casein kinase 1 (CK1) family member, is the cellular target of inhibitors YK-I-02 (YK) and MN-I-157 (MN). Here, multiplexed inhibitor beads paired with mass spectrometry (MIB/MS) employing ATP-competitive kinase inhibitors were used to define the selectivity of these Yck2 inhibitors across the global proteome.

Orphanhood and caregiver death among children in the United States by all-cause mortality, 2000-2021.

Deaths of parents and grandparent caregivers threaten child well-being owing to losses of care, financial support, safety and family stability, but are relatively unrecognized as a public health crisis. Here we used cause-specific vital statistics death registrations in a modeling approach to estimate the full magnitude of orphanhood incidence and prevalence among US children aged 0-17 years between 2000 and 2021 by cause, child age, race and ethnicity, sex of deceased parent and state, and also accounted for grandparent caregiver loss using population survey data. In 2021, we estimate that 2.