Publications by authors named "L E Comis"
Article Synopsis
- A study evaluated 229 adult patients with chronic graft-versus-host disease (cGVHD) for the prevalence and impact of metabolic syndrome (MetS), finding that 54.1% met the diagnostic criteria for MetS.
- Patients with higher body mass index and poorer performance status were more likely to have MetS, along with specific inflammatory and kidney function markers indicating its presence.
- Despite the high prevalence of MetS, there were no significant differences in survival rates or cGVHD severity between patients with and without MetS, suggesting the need for proactive screening to prevent future complications.
Article Synopsis
- A study was conducted on kidney complications specifically among patients with chronic graft-versus-host disease (cGVHD) who underwent allogeneic hematopoietic stem cell transplants, involving 365 participants.
- Out of the participants, 64 experienced kidney dysfunction, with 29 having moderate to severe issues, and those with dysfunction were more likely to have been treated with cyclosporine.
- The analysis indicated that factors like cyclosporine use and protein levels were associated with kidney dysfunction, and lower overall survival was noted in patients with moderate-severe kidney issues, highlighting the need for better management of kidney health in these patients.
Musculoskeletal symptoms in chronic graft-versus-host disease (cGVHD) are rare manifestations contributing to disease burden. This study assesses the frequency of muscle cramps, joint and muscle aches, and muscle weakness in a cohort of patients severely affected by cGVHD. Three hundred thirty-four patients participated in the NCI natural history study of cGVHD (NCT00092235) from October 2004 to March 2017.
View Article and Find Full Text PDFIntroduction: Melorheostosis is a rare bone disorder with limited literature that describes the effect of this disease on functional and motor abilities. As part of a natural history study, four outcome measures were administered to better understand the burden this disease has on a person's ability to engage in basic and instrumental activities of daily living.
Objective: To investigate the relationship between functional engagement, fatigue, and motor ability in patients with melorheostosis.
Grip myotonia and weakness are attractive treatment response biomarkers in clinical trials of myotonic dystrophy type 1 (DM1). There is a need to develop simple, patient-friendly and reproducible methods of quantifying grip myotonia in multisite trial settings. We designed a HandClench Relaxometer (HCR) that measures grip myotonia and strength.
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