Public Health.

Background: Early life-course exposome, including area-based social disadvantage, may influence the development of cognitive reserve, thereby impacting later-life incidence of Alzheimer's Disease and Related Dementias (ADRD). The primary goal of this scoping review is to evaluate the extent of literature examining early-life exposure to area-based disadvantage and its association with structural neuroanatomical differences. A secondary goal is to examine the commonalities in brain regions impacted as well as the components of the exposure-metrics utilized to study the social exposome.

Potential nuances in renoprotective properties of estrogen in females.

A current study by Kitai et al. found that ovariectomy before estrogen/female sex hormone sensitization at puberty provided protection against kidney ischemia reperfusion injury, challenging the general consensus within the field that estrogen provides renoprotective function. These results are intriguing and could have important clinical implications, while requiring some clarification and substantiation of the conclusions reported.

Comparison of Adaptive and Nonadaptive Gap Detection in Noise Test in Typically Developing Children and Adults.

Purpose:  The purpose of this study is to examine whether the gap detection thresholds (GDT) obtained are similar between an adaptive and nonadaptive procedure in children and adults.

Study Design:  Standard group comparison.

Study Sample:  Eighteen typically developing children and 20 young adults with hearing thresholds of 25 dB HL or lower participated in this study.

Efficacy and Safety of Fluocinolone Acetonide 0.19 mg Intravitreal Implant for the Treatment of Non-Infectious Uveitis: A Systematic Review of Real-World Evidence.

This systematic review evaluates the real-world efficacy and safety of the 0.19 mg fluocinolone acetonide (FAc) sustained-release intravitreal implant for treating non-infectious uveitis affecting the posterior segment of the eye (NIU-PS). Following PRISMA guidelines, a search was conducted in PubMed, Embase and Web of Science, with the latest update on September 20, 2024.

Management of twin-reversed arterial perfusion (TRAP) sequence: a systematic review and meta-analysis.

Introduction: Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic twin pregnancies characterized by placental anastomoses between a normally developed twin and an acardiac mass. Though several treatment modalities exist, the optimal management strategy is unclear. This study aims to compare the various treatment strategies for TRAP sequence.