Publications by authors named "L E Bonilla"
Background: Clinical studies in COVID-19 patients have demonstrated evidence of neuroinflammation in patients infected with SARS-CoV-2. In this pre-clinical work, we investigate neuroinflammation in vivo in a mouse model of Alzheimer's disease (AD) that exhibits both amyloid and tau pathology, the 3xTg-AD mice crossed with K18 hAce2 and infected with SARS-CoV-2 using a folate receptor-targeted nanoprobe for molecular MRI (mMRI) followed by ex vivo histopathology.
Method: In vivo studies with SARS-CoV-2 were performed in an animal biosafety level 3 (ABSL3) facility.
Acrylamide (AA) has been classified as a toxic, harmful, and carcinogenic substance since 2002, and therefore it is currently widely studied. When functional amino and carbonyl groups of asparagine and reducing sugars are condensed into Schiff bases, they are transformed into AA molecules at temperatures >120 °C. This mechanism is known as the Maillard reaction and is considered the main AA pathway.
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- Oral PrEP is highly effective in reducing HIV risk by 99% during sex and by at least 74% for people who inject drugs, and UNAIDS aims for 21.2 million individuals using PrEP by 2025.
- The CDC has played a significant role in global PrEP implementation since 2016, achieving over 2.2 million initiations from 2017 to 2023, mostly among women and young people in sub-Saharan Africa.
- Despite the progress, ongoing efforts are crucial to meet UNAIDS targets and ultimately eliminate HIV as a public health threat.
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- Secondary data sources, like administrative records and Google Maps, are often used to understand access to food, but their reliability in non-WEIRD countries is unclear.
- This study examined the accuracy of these data sources in Montevideo, Uruguay, finding that out of 1200 food outlets identified through field validation, 463 were missing from the databases and 297 listed outlets were either closed or nonexistent.
- Results showed moderate overall validity of the data, with a notable variation based on the socio-economic status of the areas, indicating caution is needed when using these data sources, especially in lower-income regions.*
Semiconductor superlattices are periodic nanostructures consisting of epitaxially grown quantum wells and barriers. For thick barriers, the quantum wells are weakly coupled and the main transport mechanism is a sequential resonant tunneling of electrons between wells. We review quantum transport in these materials, and the rate equations for electron densities, currents, and the self-consistent electric potential or field.
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