Publications by authors named "L E Baugh"
Background: It is known that being the adult child of a parent with an alcohol use disorder (ACoA) can confer a wide variety of increased health and psychological risks, including higher rates of anxiety, depression, and post-traumatic stress disorder symptoms. Additionally, ACoAs are at greater risk of developing alcohol/substance use disorders (AUDs/SUDs) than individuals from families without a history of AUDs.
Methods: ACoA individuals with risky hazardous alcohol use ( = 14) and those not engaged in hazardous use ( = 14) were compared to a group of healthy controls.
Neurostimulation/neurorecording are tools to study, diagnose, and treat neurological/psychiatric conditions. Both techniques depend on volume conduction between scalp and excitable brain tissue. Here, we examine how neurostimulation with transcranial magnetic stimulation (TMS) is affected by hydration status, a physiological variable that can influence the volume of fluid spaces/cells, excitability, and cellular/global brain functioning.
View Article and Find Full Text PDFInsulin/IGF signaling (IIS) regulates developmental and metabolic plasticity. Conditional regulation of insulin-like peptide expression and secretion promotes different phenotypes in different environments. However, IIS can also be regulated by other, less-understood mechanisms.
View Article and Find Full Text PDFBackground: There are >14,500 structurally diverse per- and polyfluoroalkyl substances (PFAS). Despite knowledge that these "forever chemicals" are in 99% of humans, mechanisms of toxicity and adverse health effects are incompletely known. Furthermore, the contribution of genetic variation to PFAS susceptibility and health consequences is unknown.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the lesser-known role of the cerebellum in PTSD by analyzing cerebellar volume differences in a large sample of 4,215 adults, with 1,642 diagnosed with PTSD and 2,573 as healthy controls.
- Using advanced deep-learning techniques, researchers assessed the total cerebellum volume and 28 subregions, revealing significant reductions in both gray and white matter in individuals with PTSD, especially in specific posterior lobe and vermis areas.
- The results suggest that changes in cerebellar structure are linked to cognitive and emotional dysfunctions in PTSD, highlighting the cerebellum's importance beyond its traditional role in motor control.