[Effect of plague "murine" toxin on activity of antioxidant system in cells of experimental animals].

Aim: To study nature of changes in components of glutathione disulfide system of experimental animals influenced by plague "murine" toxin.

Materials And Methods: Total glutathione level as well as levels of oxidated (G-SS-G) and reduced (GSH) forms of glutathione, activity of glutathione reductase and glutathione peroxidase in erythrocytes of Mongolian gerbils (Meriones unguiculatus), mice and guinea pigs were studied.

Results: Sharp decrease of reduced glutathione level as well as increase of oxidated glutathione level were observed in all experimental animal species after intraperitoneal administration of plague "murine" toxin.

[Hydrogen peroxide as an inductor of uncultivable state of Vibrio cholerae eltor in an experiment].

The influence of hydrogen peroxide on the dynamics of transition into uncultivable state (UCS) and on the reversion of V. cholerae and their subcultures, resistant to hydrogen peroxide, was studied. The transition of the initial cultures in river and distilled water into UCS took place earlier than that in resistant to hydrogen peroxide variants.

[Evaluation of hypoxic state in experimental animals induced by Yersinia pestis antigens].

Some characteristics of purine metabolism in experimental animals (white mice, clawed jirds and guinea pigs), injected intraperitoneally with Y. pestis "murine" toxin and capsular antigen (Fraction 1), were studied. Under the influence of sublethal doses of these antigens increased levels of guanine and xanthine in blood were noted.

[Morphology and enzyme activity of nonculturable forms of Vibrio cholerae].

The transition of V. cholerae into the uncultivable state under experimental conditions was accompanied by gradual changes in their morphology, motility and metabolic activity. The vibrios took the oval form, lost their flagellum, motility and enzyme activity on diagnostic media.

[Characteristics of the acid-alkali equilibrium in blood of experimental animals in response to exposure of 'murine' toxin and Yersinia pestis capsular antigen].

As revealed in this study, metabolic acidosis is observed in experimental animals the influence of "murine" toxin and Y. pestis fraction I, which is manifested by the parameters of the acid-base state, the gas composition of blood and the content of electrolytes.