Potassium channels mediate nitric oxide-induced vasorelaxation in arteries supplying colon cancer.

Introduction: Aberrant vascular function and cancer growth are closely related, with nitric oxide (NO) being a key factor in vascular tone regulation. This study provides Novel insights into the distinctive mechanisms underlying cancer-associated vascular dysfunction by investigating the involvement of potassium (K) channels in NO-mediated vasorelaxation within arteries supplying colon cancer.

Methods: Arterial segments from colon cancer patients were isolated and sectioned into rings, these rings were mounted in an organ bath filled with Krebs' solution and maintained at 37°C.

Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy - A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg.

Background: Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis.

Mapping of Health System Performance Indicators to the WHO HSPA Framework.

Healthcare systems worldwide face escalating costs and demographic changes, necessitating effective evaluation tools to understand their underlying challenges. Switzerland's high-quality yet costly healthcare system underscores the need for robust assessment methods. Existing international rankings often lack transparency and comparability, highlighting the value of structured frameworks like the Health System Performance Assessment (HSPA) by the World Health Organization (WHO).

Nutrition Education and Practice in University Dental and Oral Health Programmes and Curricula: A Scoping Review.

Introduction: Dentists and oral health practitioners have a potential role in supporting the prevention and management of noncommunicable diseases. However, the extent to which university education prepares practitioners to provide nutrition care is unclear. This scoping review identifies and synthesises the evidence related to university-level nutrition education provided to dental and oral health students globally.