Thrombotic Microangiopathy: A Devastating Complication After Lung Transplantation.

Background: Thrombotic microangiopathy (TMA) following lung transplantation (LTx) is a rare but severe complication. The pathogenesis is poorly understood, and various risk factors have been suggested. In this study, we aimed to evaluate diagnostic accuracy, identify risk factors, and assess renal, pulmonary, and overall survival of TMA in this patient group.

Endometrium-derived organoids from cystic fibrosis patients and mice as new models to study disease-associated endometrial pathobiology.

Cystic fibrosis (CF) is a life-shortening genetic disorder, caused by mutations in the CF transmembrane conductance regulator (CFTR) protein that regulates ion and fluid transport in epithelial tissue. Female CF patients face considerable fertility challenges, with higher prevalence of deficient fertility compared to healthy women. Not much is known about the underlying causes.

Clinical predictors for restrictive allograft syndrome: a nested case-control study.

Risk factors for restrictive allograft syndrome (RAS), a severe phenotype of chronic lung allograft dysfunction (CLAD) after lung transplantation, are currently not well known. In this retrospective nested case-control-study, we analyzed 69 patients with RAS and 69 matched non-CLAD controls to identify clinical risk factors for RAS. Patients with RAS demonstrated overall higher blood eosinophils (P = .

Bronchiolitis in Adults: Etiology, Diagnostic, and Therapeutic Approach.

Background: Bronchiolitis is a heterogeneous group of disorders, each with its own clinical and radiographic presentation, treatment options, and prognosis. Until now, classifications were based on pathology and radiology.

Summary: Bronchioles are smaller than 2 mm in diameter and do not contain cartilage and mucous glands in their walls.