Publications by authors named "L Duggan"
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis is identifying cell types associated with histopathological regions, particularly local fibrosis centers known as fibroblast foci. To address this, we integrated published spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) transcriptomics and adopted the Query method and the Overlap method to determine cell type enrichments in histopathological regions.
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- Fontan circulation occurs when a baby is born with only one functioning cardiac ventricle, necessitating surgeries to manage blood flow between systemic and pulmonary circulation.
- A 39-year-old male patient with Fontan physiology and a pacemaker underwent elective laparoscopic cholecystectomy, requiring careful monitoring and management of hemodynamics during surgery.
- Intraoperative monitoring with transesophageal echocardiography and the use of inhaled milrinone improved blood flow and circulation tolerance, demonstrating the importance of tailored approaches in patients with complex cardiac conditions during laparoscopic procedures.
Article Synopsis
- Alzheimer's disease (AD) is a leading cause of dementia that is fatal, and most treatments targeting amyloid beta have only limited success in slowing progression.
- Research into senescent cells (SC) and their harmful effects shows potential for new therapies, as treating aged monkeys with the senolytic drug navitoclax led to positive changes in biomarkers related to neuroinflammation and neuronal damage.
- Navitoclax was found to be safe and well tolerated in the study, suggesting its promise as a new therapeutic approach for addressing AD in humans.
Article Synopsis
- * The study focused on creating a set of expert guidelines for managing difficult airways in critically ill adults, specifically those with physiologically challenging conditions like obesity and pregnancy.
- * An international group of airway management specialists used the Delphi method, which involved multiple rounds of surveys, to achieve consensus on 53 out of 61 proposed statements regarding best practices.
- * Key recommendations included forming a robust intubation team, using videolaryngoscopy, optimizing patient conditions before intubation, and carefully monitoring the patient's status post-intubation to improve overall outcomes.
The objective of this study was to report outcomes of early cleft palate repair in infants born with Robin sequence (RS). A retrospective case series in a tertiary referral paediatric hospital was carried out, examining a consecutive series of 69 infants born with RS and cleft palate. A minimally invasive approach was taken to upper airway obstruction, with liberal nasopharyngeal airway (NPA) and non-invasive ventilation (NIV) use, guided by sleep studies.
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