Publications by authors named "L Duca"
Stiffening of the vascular network is associated with the early stages of vascular aging, leading to cardiovascular disorders (hypertension), renal failures, or neurodegenerative diseases (Alzheimer's). Unfortunately, many people remain undiagnosed because diagnostic methods are either unsuitable for a large population or unfamiliar to clinicians which favor the hypertension evaluation. In preclinical research, stiffness studies are often partially conducted.
View Article and Find Full Text PDFMetabolic dysregulation, including perturbed glutamine-glutamate homeostasis, is common among patients with cardiovascular diseases, but the underlying mechanisms remain largely unknown. Using the human MESA cohort, here we show that plasma glutamine-glutamate ratio is an independent risk factor for carotid plaque progression. Mice deficient in glutaminase-2 (Gls2), the enzyme that mediates hepatic glutaminolysis, developed accelerated atherosclerosis and susceptibility to catastrophic cardiac events, while Gls2 overexpression partially protected from disease progression.
View Article and Find Full Text PDFAnemia during acute inflammation is not well described in the literature. We aimed to study whether patients develop a transient hemoglobin decrease during an acute attack of recurrent pericarditis. We retrospectively analyzed patients with recurrent pericarditis.
View Article and Find Full Text PDFArticle Synopsis
- Anemia and hyperferritinemia are common at the onset of Gaucher disease, affecting 41% and 51% of patients respectively.
- Over a 5-year period, enzyme replacement therapy (ERT) significantly improved hemoglobin levels, decreased markers of ineffective erythropoiesis, and reduced serum ferritin, indicating better iron metabolism.
- The study highlights the important role of iron dysregulation in anemia for Gaucher disease patients and shows that ERT enhances both erythropoiesis and iron handling.