Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.

BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTSParticipants with T1D had significantly higher glomerular basement membrane (GBM) thickness compared with HCs.

A high-power 4 × 4: crystallographic and electrochemical insights into a novel Wadsley-Roth anode NbTiWO.

A novel 4 × 4 Wadsley-Roth block phase, NbTiWO, has been prepared and its structure determined through Neutron and X-ray diffraction studies. Electrochemical testing indicated excellent high rate performance, with a returned delithiation capacity of 184 (4) mA h g at a current of 2 A g.

Flexible multitask computation in recurrent networks utilizes shared dynamical motifs.

Flexible computation is a hallmark of intelligent behavior. However, little is known about how neural networks contextually reconfigure for different computations. In the present work, we identified an algorithmic neural substrate for modular computation through the study of multitasking artificial recurrent neural networks.

Kidney Energetics and Cyst Burden in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study.

Rationale & Objective: In this pilot study, we hypothesized that autosomal dominant polycystic kidney disease (ADPKD) is characterized by impaired kidney oxidative metabolism that associates with kidney size and cyst burden.

Study Design: Cross-sectional study.

Setting & Participants: Twenty adults with ADPKD (age, 31±6 years; 65% women; body mass index [BMI], 26.