The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding.

The compound, LY368975 ((R)-thionisoxetine) is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. We evaluated the in vivo properties of LY368975 in various animal models. In mice, LY368975 prevented heart NE depletion by 6-hydroxydopamine with an ED50 of 1.

Greater effects of fluoxetine and its combination with (-)-pindolol in elevating hypothalamic serotonin in rats during dark hours.

Administration of fluoxetine (10 mg/kg i.p.) caused a significantly greater increase in extracellular 5-HT levels in hypothalamus of rats adapted to a reverse light period (lights off 9:00 am-9:00 pm) than those adapted to the regular cycle (lights off 6:00 pm-6:00 am).

Enhancement of fluoxetine-dependent increase of extracellular serotonin (5-HT) levels by (-)-pindolol, an antagonist at 5-HT1A receptors.

The somatodendritic 5-HT1A autoreceptor is known to regulate activity of 5-HT neurons and consequently 5-HT release. Administration of a selective 5-HT uptake inhibitor, fluoxetine (10 mg/kg, i.p.

Age-dependent taste preferences in rabbits for a .025% sodium saccharin solution: preliminary findings.

Classical conditioning of rhythmic jaw movements in rabbits is an accepted model of associative learning that may be useful in assessing age-related changes in learning and motivation. A saccharin solution has been thought to be rewarding to rabbits and is often used as an unconditioned stimulus (US). To determine whether age-related differences in preference for saccharin exist, we assessed (a) saccharin versus water preferences and (b) fluid intake level differences (which might account for differing drive levels) in young (4-6 months) and old (31-69 months) rabbits.