Publications by authors named "L Dostalek"
Article Synopsis
- People with T1a cervical cancer usually do well, but there's still a chance their cancer might come back, and doctors need better guidance on how to manage this.
- A study looked at over 900 patients from different hospitals to find out more about the chances of cancer returning after surgery.
- The study found that only 4.1% of patients had their cancer return, and it happened more often in certain groups, showing that certain things like lymphovascular space invasion (LVSI) can change the risk.
Aim: The aim of this study was to assess whether the use of sentinel lymph node (SLN) in addition to lymphadenectomy was associated with survival benefit in patients with early-stage cervical cancer.
Methods: International, multicenter, retrospective study.
Inclusion Criteria: cervical cancer treated between 01/2007 and 12/2016 by surgery only; squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, FIGO 2009 stage IB1-IIA2, negative surgical margins, and laparotomy approach.
Article Synopsis
- - The study focuses on identifying risk factors for anal and oral HPV infections in women with severe cervical lesions (CIN2+) and confirms the link between HPV and cancer in both anogenital and oropharyngeal areas.
- - Strongest risk factors for anal HPV included existing cervical HPV infection, having ten or more sexual partners, and engaging in anal-penetrative intercourse, while for oral HPV, a history of genital warts in the woman or her male partner was significant.
- - The findings suggest that HPV infection in one area (like the cervix) increases the likelihood of infection in another area (like the anus or mouth), highlighting different routes and risk factors for transmission across bodily sites.
Objective: The management and surveillance of glandular pre-cancerous lesions of the uterine cervix present distinct challenges compared with squamous lesions, primarily attributed to the lower effectiveness of diagnostic methods such as cytology or colposcopy. This study aimed to investigate the long-term safety of fertility-sparing treatment for adenocarcinoma in situ and microinvasive adenocarcinoma of the cervix, while identifying factors associated with recurrence, with a particular emphasis on the role of human papillomavirus (HPV) testing.
Methods: We retrospectively reviewed data from all patients with histopathologically confirmed adenocarcinoma in situ or microinvasive cervical adenocarcinoma who received treatment at a single center between 2002 and 2023.
Analysis of cell-free DNA methylation (cfDNAme), alone or combined with CA125, could help to detect ovarian cancers earlier and may reduce mortality. We assessed cfDNAme in regions of ZNF154, C2CD4D and WNT6 via targeted bisulfite sequencing in diagnostic and early detection (preceding diagnosis) settings. Diagnostic samples were obtained via prospective blood collection in cell-free DNA tubes in a convenience series of patients with a pelvic mass.
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