Publications by authors named "L Dossus"
Association between chronic long-term exposure to airborne dioxins and breast cancer.
Int J Hyg Environ Health
January 2025
Article Synopsis
- Breast cancer is the most common cancer in women, and environmental pollutants, particularly endocrine disruptors like dioxins, may influence its development.
- A study analyzed the link between airborne dioxin exposure and breast cancer risk in a cohort of 5222 cases and 5222 controls, using data about their proximity to dioxin sources and other factors.
- The results indicate a slight increase in breast cancer risk with higher cumulative dioxin exposure, suggesting the need for measures to reduce air pollution exposure.
Background: An increasing number of studies in recent years investigate various dietary and lifestyle patterns and associated breast cancer (BC) risk.
Objectives: This study aimed to comprehensively synthesize and grade the evidence on dietary and lifestyle patterns and BC risk.
Methods: Databases were systematically searched up to 31 March, 2022, for evidence from randomised controlled trials and prospective cohort studies on adherence to a dietary pattern alone or in combination with lifestyle behaviors and incidence of or mortality from primary BC in adult females.
Article Synopsis
- Inflammation plays a significant role in breast cancer progression and prognosis, particularly through pre-diagnostic plasma biomarkers in women.
- A study involving 1,538 women showed that elevated levels of the inflammatory marker IL-6 were linked to increased risks of all-cause and breast cancer-specific mortality, especially in postmenopausal women.
- Higher levels of IL-10 and TNFα were also associated with all-cause mortality, and an inflammatory score could indicate poorer long-term survival, particularly in postmenopausal breast cancer survivors.
Article Synopsis
- Obesity is linked to increased cancer risk, but differences in risk based on metabolic health status are not well understood; this study reviews associations between different metabolic obesity types and cancer risk.
- Researchers screened over 15,500 records, ultimately including 31 studies, with most being at low risk of bias; findings indicate that metabolically unhealthy overweight/obese individuals are at a higher risk for overall and certain specific cancers compared to metabolically healthy normal-weight individuals.
- Specific cancers with increased risk among metabolically unhealthy overweight/obese, include endometrium (2.31 times), kidney (1.71 times), and breast cancers, with varying levels of certainty in the data.
Background: Inflammation and immune dysregulation are hypothesized contributors to endometrial carcinogenesis; however, the precise underlying mechanisms remain unclear.
Methods: We measured pre-diagnostically 152 plasma protein biomarkers in 624 endometrial cancer case-control pairs nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Odds ratios (ORs) were estimated using conditional logistic regression, accounting for confounding and multiple comparisons.