Publications by authors named "L Don Gilmore"
Background/objectives: Despite strong evidence that breastfeeding, skin-to-skin care, and sucrose reduce pain in newborns during minor painful procedures, these interventions remain underutilized in practice. To address this knowledge-to-practice gap, we produced a five-minute parent-targeted video demonstrating the analgesic effects of these strategies and examined whether the use of newborn pain treatment increased in maternal-newborn care settings following the introduction of the video by nurses.
Methods: The design was a pre-post outcome evaluation.
Article Synopsis
- - The EXACT trial, sponsored by the National Cancer Institute, aims to evaluate whether 150 minutes of weekly moderate-intensity aerobic exercise can lower systemic inflammation in stage I-III colorectal cancer survivors compared to a control group over 12 weeks.
- - Recruitment for the study involved inviting over 3,000 survivors, with 89 screened and 60 randomized, revealing that younger age, female sex, and certain racial and clinical factors positively influenced participation.
- - Findings showed high exercise adherence at 92.2%, with all participants meeting the 80% adherence goal, and the trial will provide insights into how exercise may help prevent cancer recurrence and improve survival rates.
Background: Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways.
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