Does insulin down-regulate its own receptor on erythrocytes in vitro?

The purpose of this study was to examine the in vitro effect of insulin on its own receptors on erythrocytes. Whole blood from 6 fasting normal and 6 diabetic (type II) subjects was incubated without or with exogenous insulin for 5 hours. The insulin binding to erythrocytes was then evaluated.

Studies of diabetic polyneuropathy using conduction velocity distribution (DCV) analysis.

The distributions of nerve fiber conduction velocities (DCVs) derived from the median nerves of 29 adult diabetic patients (mean age, 52.1 +/- 12.3 years) with mild or no symptoms or signs of polyneuropathy were compared with DCVs from 34 age-appropriate normal subjects.

Insulin receptor binding and insulin-mediated glucose uptake in type-II-diabetics.

A 5-hour insulin clamp was performed in 7 normal subjects (N) and 6 type-II-diabetics. After a 10-min-priming insulin infusion, a constant infusion of 1.813 micrograms/m2 s.

Effect of age on glucose tolerance, insulin secretion, and in vivo insulin action.

The effect of age on glucose tolerance, insulin secretion, and in vivo insulin action (insulin clamp) was studied in 48 nonobese subjects, all of whom were fully ambulatory and in good general health. The observed age-related increase in fasting plasma glucose (r = 0.35, P less than 0.

Lipid metabolism in non-insulin-dependent diabetes mellitus: effect of glipizide therapy.

Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (+/- SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio.