Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.

The gut microbiome modulates the anti-seizure effects of the ketogenic diet, but how specific dietary formulations differentially modify the gut microbiome in ways that impact seizure outcome is poorly understood. We find that medical ketogenic infant formulas vary in macronutrient ratio, fat source, and fiber content and differentially promote resistance to 6-Hz seizures in mice. Dietary fiber, rather than fat ratio or source, drives substantial metagenomic shifts in a model human infant microbial community.

Relating production and perception in two Raglai dialects at different stages of registrogenesis.

This paper explores the perception of two diachronically related and mutually intelligible phonological oppositions, the onset voicing contrast of Northern Raglai and the register contrast of Southern Raglai. It is the continuation of a previous acoustic study that revealed that Northern Raglai onset stops maintain a voicing distinction accompanied by weak formant and voice quality modulations on following vowels, while Southern Raglai has transphonologized this voicing contrast into a register contrast marked by vowel and voice quality distinctions. Our findings indicate that the two dialects partially differ in their use of identification cues, Northern Raglai listeners using both voicing and F1 as major cues while Southern Raglai listeners largely focus on F1.

The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment.

Background: In our previous study, we demonstrated that headaches are highly prevalent among medical students in Vietnam. In the present study, we provide estimates of the associated symptom burden and impaired participation, utilizing these estimates to assess headache-related healthcare needs within this population.

Methods: The study followed the standardized methodology established by the Global Campaign against Headache.

Redundant voicing and register in Mnong Râlâm.

Mnong Râlâm is a South Bahnaric language (Austroasiatic) that is traditionally described as preserving a voicing contrast in onset obstruents, contrary to other languages of the Mnong/Phnong continuum. Acoustic results yield evidence that this voicing distinction is less robust than previously suggested and is redundant with a register contrast realized on following vowels through modulations of F1 at vowel onset (and more limited variations of F2 and voice quality). A perception experiment also shows that F1 weighs heavier than closure voicing in identification.

An updated overview on long-acting therapeutics for the prevention and treatment of human immunodeficiency virus (HIV) from a perspective of pharmaceutics.

Conventional drug formulations release active pharmaceutical ingredients (APIs) immediately after administration, while long-acting (LA) drug products are designed for prolonged therapeutic effects, thereby reducing administration frequency and improving patient compliance. The development of LA therapeutics for chronic disease treatment has significantly helped patients adhere to their regimens, reducing the need for daily doses and easing the burden on healthcare systems. Advances in treatment have transformed Human Immunodeficiency Virus (HIV) into a manageable chronic disease, and efforts are underway to eliminate HIV in the future.