Publications by authors named "L Diez"
Introduction: A positive surgical margin (R1 resection) is a relevant risk factor for local recurrence in patients with pancreatic ductal adenocarcinoma of the pancreas (PDAC). An intraoperative liquid biopsy (ILB) based on tumor cell mobilization could help to detect R1 resection intraoperatively.
Objective: To evaluate the potential role of the intraoperative circulating tumor cells (CTCs) and cluster mobilization on the R0/R1 detection.
Article Synopsis
- Idiopathic REM sleep behavior disorder (iRBD) is linked to alpha-synucleinopathies, and the study aimed to evaluate autonomic nervous system (ANS) dysfunction in individuals with iRBD and its potential to predict clinical progression.
- In a study of 25 iRBD patients, 28% developed synucleinopathy, primarily Parkinson's disease, with many exhibiting abnormal ANS test results; those who progressed had significantly higher rates of dysfunction compared to those who did not.
- Results indicate that both symptomatic and subtle ANS dysfunctions are prevalent in iRBD, and specific adrenergic system issues may signal a higher short-term risk of developing synucleinopathy.
Article Synopsis
- The study investigates two surgical approaches (no-touch vs. superior mesenteric artery) in patients undergoing pancreatoduodenectomy for pancreatic ductal adenocarcinoma, focusing on circulating tumor cells during surgery.
- *Patients were randomly assigned to each group, and samples were taken to measure tumor cell activity at different surgical stages.
- *Results showed no significant differences in tumor cell mobilization or metastasis-free survival between the two approaches, but patients with tumor cell clusters mobilized during surgery had a higher rate of distant metastases within the first year.
Continuous High-Precision Positioning in Smartphones by FGO-Based Fusion of GNSS-PPK and PDR.
Micromachines (Basel)
September 2024
The availability of raw Global Navigation Satellites System (GNSS) measurements in Android smartphones fosters advancements in high-precision positioning for mass-market devices. However, challenges like inconsistent pseudo-range and carrier phase observations, limited dual-frequency data integrity, and unidentified hardware biases on the receiver side prevent the ambiguity resolution of smartphone GNSS. Consequently, relying solely on GNSS for high-precision positioning may result in frequent cycle slips in complex conditions such as deep urban canyons, underpasses, forests, and indoor areas due to non-line-of-sight (NLOS) and multipath conditions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates changes in IgE sensitization to common allergens like dust mites, cats, dogs, and cockroaches over a 10-year period among patients with asthma, rhinitis, and atopic dermatitis.
- Results from 6,000 patient records indicate that 82% of individuals had sensitization to at least one allergen, with dust mites being the most common, and the exposure to certain allergens, such as Blomia tropicalis, increasing over time.
- The findings suggest that early exposure to dust mites is crucial for developing sensitization to other allergens, while exposure to pets, especially cats, is linked to a higher risk of developing atopy.