Publications by authors named "L Diancourt"
This study reports a botulism outbreak on a pig farm. Clostridium botulinum type C was detected using PCR. The gene encoding the toxin corresponds to a novel type C neurotoxin recently described in a human botulism outbreak, raising the question of its prevalence in pigs and the related risks to humans.
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- The study focuses on ribotype (RT) 002, linked to severe healthcare-associated infections like colitis, by analyzing the genetic characteristics of 537 genomes associated with MLST sequence type (ST) 8.
- Researchers sequenced 298 strains from a new European collection, comparing them with a global dataset of 1,437 ST8 genomes, revealing genetic similarity, diverse antimicrobial resistance genes, and an open genomic structure.
- Results indicate that while ST8 shows low overall variation and stability across different environments, it can still acquire antimicrobial resistance genes, highlighting the need for ongoing surveillance of non-human sources to better understand its epidemiology.
Article Synopsis
- The text discusses a rare case of bacteremia caused by a strain of an anaerobic, spore-forming Gram-positive bacterium associated with severe infections like necrotizing gangrene and gastrointestinal issues.
- In 2014, a new toxin called BEC was identified, which can lead to acute gastroenteritis in humans; the text highlights a 64-year-old man who developed pneumonia and septic shock, ultimately passing away despite treatment.
- Whole genome sequencing of the bacteria found in the patient revealed various virulence factors, including the newly discovered BEC toxin, and confirmed a significant genetic diversity among BEC-producing strains.
Background: Clostridium neonatale was isolated during an outbreak of neonatal necrotizing enterocolitis (NEC) in 2002. C. neonatale was validated as a new species within the genus Clostridium sensu stricto in 2018.
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