Publications by authors named "L Di Iorio"
A variety of scientific fields like proteomics and spintronics have created a new demand for on-chip devices capable of sensing parameters localized within a few tens of micrometers. Nano and microelectromechanical systems (NEMS/MEMS) are extensively employed for monitoring parameters that exert uniform forces over hundreds of micrometers or more, such as acceleration, pressure, and magnetic fields. However, they can show significantly degraded sensing performance when targeting more localized parameters, like the mass of a single cell.
View Article and Find Full Text PDFArticle Synopsis
- VEXAS syndrome is a newly identified autoinflammatory disorder caused by mutations in the UBA1 gene, particularly observed in blood progenitor cells, with a notable characteristic of having vacuoles present in these cells.
- The study aimed to compare blood samples from VEXAS patients against those with other conditions (ANCA-associated vasculitis and familial Mediterranean fever) and healthy individuals to find specific features that aid in diagnosing VEXAS.
- Results indicated that VEXAS patients had more immature neutrophils and a higher number of vacuoles compared to controls, with a strong correlation between higher cell death rates and elevated levels of inflammatory markers, suggesting that cytological tests could
Objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is frequently associated with refractory chronic rhinosinusitis with nasal polyps (CRSwNP), despite current treatments. Dupilumab demonstrated efficacy in the treatment of severe and uncontrolled CRSwNP, with improvements in patient-reported outcome measures and in objective measurements. This study aims to evaluate efficacy and safety of dupilumab in refractory CRSwNP in EGPA patients.
View Article and Find Full Text PDFThermoplastic fiberglass was compression molded in the form of thick panels with a nominal thickness of 10 mm and a size of 300 × 300 mm. A simplified procedure was adopted to speed up the lamination procedure and adapt it to the aim of recycling waste, glass fibers, fabrics, and thermoplastic films. Low density polyethylene was used as a matrix to simplify the laboratory process, but the same procedure can be extended to other thermoplastic film, such as polyamide.
View Article and Find Full Text PDFArticle Synopsis
- Drug-induced vasculitis is a common type that mimics ANCA vasculitis, often linked to cocaine and levamisole use.
- These substances lead to various autoimmune conditions, including cocaine-induced midline destructive lesions and forms of vasculitis, creating a complex overlap in symptoms.
- The exact mechanisms of how cocaine causes these autoimmune issues remain unclear, complicating diagnosis and treatment, especially when there's no suspicion of drug abuse.