Publications by authors named "L Di Chiara"
Article Synopsis
- * In a study of pediatric and adult patients, a significant portion showed IgG antibodies localizing to kidney proteins, but the presence of these antibodies varied, indicating potential involvement of other proteins.
- * Patients with anti-slit antibodies were more likely to develop nephrotic syndrome and showed a higher response rate to second-line immunosuppressants, while those without these antibodies had a greater risk of kidney failure.
Article Synopsis
- Cholesterol crystal embolism (CCE) leads to serious health issues like tissue damage and organ failure, with no specific treatments available.
- Researchers tested the idea that blocking the C5a/C5aR pathway could help reduce the harmful effects of CCE, similar to how it works in systemic vasculitis.
- Experiments in mice showed that blocking C5a or its receptor before or after cholesterol crystal injection significantly prevented kidney damage and other severe outcomes, suggesting potential for treatment in at-risk patients.
The use of allogeneic blood products to restore hemostasis during pediatric cardiac surgery is associated with major risks. Consequently, there has been a growing interest in new patient blood management strategies, such as those based on the use of fibrinogen concentrate (FC). Accumulating evidence has shown FC supplementation to be safe and effective.
View Article and Find Full Text PDFThe complex and dynamic environment of the gastrointestinal tract shapes one of the fastest renewing tissues in the human body, the intestinal epithelium. Considering the lack of human preclinical studies, reliable models that mimic the intestinal environment are increasingly explored. Patient-derived intestinal organoids are powerful tools that recapitulate in vitro many pathophysiological features of the human intestine.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how social restrictions and different variants, specifically Alpha, Delta, and Omicron-BA.1, affected the spread of SARS-CoV-2 in Galicia, Spain.
- Using genomic data and mobility statistics, the research found that initial variant introductions mostly came from other Spanish regions and France, later shifting to include imports from Portugal and the U.S.
- Despite the number of introductions, most did not contribute significantly to the pandemic's evolution in Galicia, but major coastal cities were identified as key areas for viral transmission.