Health risk assessment of ciprofloxacin, tetracycline, and oxytetracycline residues in raw, frozen, and boiled broiler chicken available in a local area of Bangladesh.

Introduction: The misuse of antibiotics in poultry farming is a global issue.

Objective: The focus of this study was the health risk assessment of consumers from the determination of ciprofloxacin (CIP), tetracycline (TC), and oxytetracycline (OTC) in broiler chicken in the raw, frozen, and boiled stages using solid-phase extraction, high-performance liquid chromatography, and ultraviolet detection (SPE-HPLC-UV).

Materials And Methods: Chromatographic separation was achieved using 0.

Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance.

Glyoxalase 2 (Glo2) is an enzyme of the glyoxalase system whose pathway parallels glycolysis and which aims to remove methylglyoxal (MGO). This study analyzed the possible additional roles of the Glo2 enzyme in breast cancer (MCF7) and non-cancer (HDF) cell lines, investigating its presence at the nuclear level and its potential involvement in cell proliferation and chemotherapy resistance. The results revealed that Glo2 is overexpressed in cancer cells, and its expression is higher during the proliferative (S and G2/M) phases of the cell cycle.

Strong Non-Reciprocal Chiroptical Properties in Thin Films of Chiral Alkylthio-Decorated 1,4-Phenylene/Thiophene Dyes.

In the context of chiral π-conjugated materials, the use of enantiopure alkylthio appendages represents a valid alternative to conventional alkoxy groups: sulphur atom is bigger and more electron-rich than oxygen, thus allowing for higher polarizability, greater flexibility, larger bulkiness and lower structural anisotropy. In light of these considerations, here we report two new chiral alkylthio-decorated 1,4-phenylene/thiophene dyes, obtained by simple synthetic strategies involving Pd-catalyzed cross-coupling protocols, looking for strong non-reciprocal chiroptical features in thin films. In particular, for the chiral alkylthio-decorated 1,4-phenylene-bis(thiophenylpropynone) (Thio-PTPO) dye, which proved to be the most promising for our purpose, a detailed investigation in thin films was carried out, involving optical and chiroptical spectroscopies in absorption and emission, as well as optical microscopy techniques.